Löwenberg EC, Meijers JC, Monia BP, Levi M. J Thromb Haemost. 2010 Nov;8(11):2349-57. doi: 10.1111/j.1538-7836.2010.04031.x. Coagulation factor (F)XI was first described as a member of the contact pathway of coagulation. However, the ‘classic’ theory of the extrinsic and intrinsic pathway has been revised and FXI was found to be activated by thrombin and to play a role in sustained [...]
View Post factor XI, thromboembolic, thrombosisPham M, Stoll G, Nieswandt B, Bendszus M, Kleinschnitz C. J Mol Med (Berl). 2012 Feb;90(2):119-26. Epub 2011 Sep 10. Ischemic stroke is a devastating disease which, in most cases, is caused by thrombotic occlusion of brain arteries. The molecular mechanisms involved in microvascular thrombus formation during focal cerebral ischemia are not well understood. As a consequence, the current antithrombotic [...]
View Post factor XII, fibrin, ischemic stroke, thromboembolismLuo D, Szaba FM, Kummer LW, Johnson LL, Tucker EI, Gruber A, Gailani D, Smiley ST. Infect Immun. 2012 Jan;80(1):91-9. Epub 2011 Oct 17. In mice infected sublethally with Listeria monocytogenes, fibrin is deposited at low levels within hepatic tissue, where it functions protectively by limiting bacterial growth and suppressing hemorrhagic pathology. Here we demonstrate that mice infected with lethal doses of L. [...]
View Post bacterial growth, coagulopathy, factor XI, fibrin, inflammation, listeria, listeriosisHe R, Chen D, He S. Thromb Res. 2011 Dec 22. [Epub ahead of print] Coagulation factor FXI (FXI), a plasma serine protease zymogen, has important roles in both intrinsic and extrinsic coagulation pathways and bridges the initiation and amplification phases of plasmatic hemostasis. Recent studies have provided new insight into the molecular structure and functional features of [...]
View Post antithrombotics, FXI, fXIIaVicente CP, Weiler H, Di Cera E,Tollefsen DM. Thromb Res. 2011 Dec 16. The thrombin mutant W215A/E217A (WE thrombin) has greatly reduced procoagulant activity, but it activates protein C in the presence of thrombomodulin and inhibits binding of platelet glycoprotein Ib to von Willebrand factor and collagen under flow conditions. Both thrombomodulin-dependent protein C activation [...]
View Post E217A, protein C activation, von Willebrand factor, W215A/E217A, WE-thrombinDi Cera E. Prog Mol Biol Transl Sci. 2011;99:145-84. Thrombosis is the most prevalent cause of fatal diseases in developed countries. An antithrombotic agent that can be administered to patients with severe acute thrombotic diseases without the risk of causing hemorrhage, as experienced with antithrombotic/thrombolytic therapy in the treatment of acute ischemic stroke or systemic anticoagulants [...]
View Post antithrombotic, ischemic stroke, protease-activated receptors, Protein C, protein C activation, thrombolytic therapy, thrombosisMüller F, Gailani D, Renné T. Curr Opin Hematol. 2011 Sep;18(5):349-55. Arterial and venous thrombosis are major causes of morbidity and mortality, and the incidence of thromboembolic diseases increases as a population ages. Thrombi are formed by activated platelets and fibrin. The latter is a product of the plasma coagulation system. Currently available anticoagulants such as heparins, vitamin [...]
View Post Anticoagulation, arterial thrombosis, factor Xa, fibrin, fibrin formation, hemostasis, Thrombin, thromboembolic, VENOUS THROMBOSISNieswandt B, Kleinschnitz C, Stoll G. J Physiol. 2011 Sep 1;589(Pt 17):4115-23. Epub 2011 Jul 18. Ischaemic stroke is a leading cause of death and disability worldwide. The complex cellular interactions leading from thromboembolic vessel occlusion to infarct development within the brain parenchyma in acute stroke are poorly understood, which translates into only one approved effective treatment, thrombolysis. [...]
View Post factor XII, ischemic stroke, von Willebrand factorWong PC, Crain EJ, Watson CA, Schumacher WA. J Thromb Thrombolysis. 2011 Aug;32(2):129-37. BMS-262084 is a 4-carboxy-2-azetidinone-containing irreversible inhibitor of FXIa, which is selective over other coagulation proteases. We evaluated the in vitro and in vivo properties of BMS-262084 in rabbits. Studies were conducted in arteriovenous-shunt thrombosis (AVST), venous thrombosis (VT), electrolytic-mediated carotid arterial thrombosis (ECAT) and cuticle bleeding [...]
View Post antithrombotic, Factor XIaFurlan-Freguia C, Marchese P, Gruber A, Ruggeri ZM, Ruf W. J Clin Invest. 2011 Jul;121(7):2932-44. doi: 10.1172/JCI46129. Epub 2011 Jun 13. Thrombosis is initiated by tissue factor (TF), a coagulation cofactor/receptor expressed in the vessel wall, on myeloid cells, and on microparticles (MPs) with variable procoagulant activity. However, the molecular pathways that generate prothrombotic TF in vivo are poorly defined. [...]
View Post prothrombotic, thrombosis